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KMID : 0371320020620050366
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Journal of the Korean Surgical Society
2002 Volume.62 No. 5 p.366 ~ p.370
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Imaging of Estrogen Receptors with Iodine-123- Iabeled Estradiol in Primary Breast Cancer Patients
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Park Kwang-In
Noh Woo-Chul
Lee Ryung-Ah
Choi Chang-Woon
Bang Ho-Yoon
Hwang Dae-Yong
Choi Dong-Wook
Lee Jong-Inn
Paik Nam-Sun
Moon Nan-Mo
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Abstract
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Purpose: We evaluated the feasibility of non-invasive imaging of estrogen receptors (ER) in primary breast cancer with iodine-123-labeled ER specific ligand (17α,20E)-21-[123I] iodo-19-nonpregna-1,3,5-(10), 20-tetraene-3,
17-diol
using conventional nuclear medicine technique.
Methods: Before they underwent surgical management, planar scintigraphy and single-photon emission computed tomography (SPECT) were performed in 18 patients with proven primary breast cancer, after single Ⅳ injection of 5~10 mCi
I-123-estradiol.
The results were compared with those of immunohistochemical staining against ER of the surgical specimens.
Results: Planar and SPECT imaging showed hot uptake in nine of eighteen (50%) breast cancer patients. The results of ER immunohistochemistry were all positive in these patients. In the 9 cases of negative scintigraphy, 8 showed negative
staining
results but one showed positive staining results. Therefore, the overall concordance rate of ER scintigraphy and ER immunohistochemistry was 94.4% (17/18).
Conclusions: ER scintigraphy using I-123-estradiol is a highly predictable in vivo technique to detect ER-positive breast cancer preoperatively. It has potential application as a reliable diagnostic modality and indicator of hormone therapy
for
breast cancer patients.
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KEYWORD
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